Gao ZY, Liu Z, Bi MH, Zhang JJ, Han ZQ, Han X, Wang HY, Sun GP, Liu H (2016) Metformin induces apoptosis via a mitochondria-mediated pathway in human breast cancer cells in vitro
Within the cytosol of cells, glutathione is kept primarily in the reduced GSH form, largely by reduction of GSSG by the enzyme glutathione reductase, at the expense of NADPH: The mechanism of this reaction is complex, as the enzyme contains a pair of cysteine residues that reversibly form a disulfide bond, plus one FAD molecule (3)
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Myers, S.P
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